On November 2, 2025, an exciting NFL matchup is set as the Indianapolis Colts visit the Pittsburgh Steelers at Acrisure Stadium in Pittsburgh, with kickoff scheduled for 1:00 PM. In the impressive standings of the 2024 NFL season, the Colts find themselves first in their division and fourth in the AFC with a record of 3-1, showcasing a robust winning percentage of 0.75. They’ve accumulated 123 points for and 83 against, giving them a positive point difference of 40. On the other hand, the Steelers, also at the top of their division and second in the AFC, have an identical record of 3-1 and a winning percentage of 0.75, scoring 96 points while allowing 98, resulting in a net point difference of -2. Last weekend, the Colts edged out Miami 16-10 at Lucas Oil Stadium, gaining 155 rushing yards and 129 passing yards. Anthony Richardson, leading the Colts, threw for 129 yards. Meanwhile, the Steelers had a dominant 37-15 win against the New York Jets, with Russell Wilson throwing for 260 yards and two touchdowns, showcasing his formidable form with a passer rating of 108.98. The preceding performances of Richardson and Wilson set a tantalizing stage for this confrontation. Let’s delve into the betting aspect: the Steelers are favored with a point spread of -3.50 against the Colts at +3.50. For those inclined towards total points betting, the over/under is pegged at 44.70. Moneyline odds see the Steelers at -181 and the Colts at +151. This suggests a slightly favored position for Pittsburgh in what is expected to be a closely contested battle. For continuous updates, keep an eye on betOregonsports.com.